DynaMut2 Result · RareResearch.AI Molecular Atlas
WFS1 A716T — Predicted Stability Change
Computed on AlphaFold AF-O76024-F1 v6 · Job ID 177985952865 · Biosig Lab, University of Queensland / Melbourne
ΔΔG (Stability Change)
-0.8kcal/mol
Destabilising
Mutation Details
- Chain
- A
- Position
- 716
- Wild-type
- A (Alanine)
- Mutant
- T (Threonine)
- Region
- C-terminal lumenal domain (653-869)
Mechanistic Interpretation
Adding a polar hydroxyl group where a hydrophobic methyl sat. Small chemical change with mild local destabilization — but the variant produces autosomal dominant DFNA6 hearing loss, suggesting a dominant-negative mechanism not captured by monomer ΔΔG.