DynaMut2 Result · RareResearch.AI Molecular Atlas
WFS1 F264L — Predicted Stability Change
Computed on AlphaFold AF-O76024-F1 v6 · Job ID 177992494543 · Biosig Lab, University of Queensland / Melbourne
ΔΔG (Stability Change)
0.19kcal/mol
Stabilising — but value is NOT trustworthy (see warning below)
Interpretation warning. Position 264 sits in wolframin's intrinsically disordered region (pLDDT 47.03, below the 50 threshold). DynaMut2 assumes a meaningful input structure; for IDR residues that assumption is violated. The ΔΔG value should NOT be used to make clinical or therapeutic decisions. Route to wet-lab experimental validation.
Mutation Details
- Chain
- A
- Position
- 264
- Wild-type
- F (Phenylalanine)
- Mutant
- L (Leucine)
- Region
- N-terminal cytoplasmic domain (87-313)