DynaMut2 Result · RareResearch.AI Molecular Atlas
WFS1 G656C — Predicted Stability Change
Computed on AlphaFold AF-O76024-F1 v6 · Job ID 178092141279 · Biosig Lab, University of Queensland / Melbourne
ΔΔG (Stability Change)
-0.47kcal/mol
Destabilising — but value is NOT trustworthy (see warning below)
Interpretation warning. Position 656 sits in wolframin's intrinsically disordered region (pLDDT 48.88, below the 50 threshold). DynaMut2 assumes a meaningful input structure; for IDR residues that assumption is violated. The ΔΔG value should NOT be used to make clinical or therapeutic decisions. Route to wet-lab experimental validation.
Mutation Details
- Chain
- A
- Position
- 656
- Wild-type
- G (Glycine)
- Mutant
- C (Cysteine)
- Region
- C-terminal ER-lumenal (calcium binding, calmodulin, chaperone)