DynaMut2 Result · RareResearch.AI Molecular Atlas
WFS1 G695V — Predicted Stability Change
Computed on AlphaFold AF-O76024-F1 v6 · Job ID 177985955825 · Biosig Lab, University of Queensland / Melbourne
ΔΔG (Stability Change)
-0.84kcal/mol
Destabilising
Mutation Details
- Chain
- A
- Position
- 695
- Wild-type
- G (Glycine)
- Mutant
- V (Valine)
- Region
- C-terminal lumenal domain (653-869)
Mechanistic Interpretation
Glycine has no side chain; valine is branched and bulky. Predicted as severe destabilization, came back mild — wolframin's C-terminal lumenal fold accommodates the bulkier residue better than expected. Pathogenicity likely via specific functional contact disruption.