DynaMut2 Result · RareResearch.AI Molecular Atlas
WFS1 L543R — Predicted Stability Change
Computed on AlphaFold AF-O76024-F1 v6 · Job ID 177985958201 · Biosig Lab, University of Queensland / Melbourne
ΔΔG (Stability Change)
-1.75kcal/mol
Destabilising
Mutation Details
- Chain
- A
- Position
- 543
- Wild-type
- L (Leucine)
- Mutant
- R (Arginine)
- Region
- TM7 (529-549), helical transmembrane
Mechanistic Interpretation
Inserting a permanently charged arginine into the hydrophobic lipid bilayer interior. Largest magnitude of the pilot set (-1.75 kcal/mol) but still below the Cat 2 threshold — likely because nearby polar residues in TM7 provide partial compensation.