# T321M — WFS1 Molecular Atlas Card

**Variant type:** Missense
**Substitution:** Threonine (T) → Methionine (M) at position 321
**Domain context:** Transmembrane helix 1

---

## AlphaMissense

- **Pathogenicity score:** 0.1462
- **Class:** likely benign

## AlphaFold confidence

- **pLDDT at residue 321:** 75.12

> **DynaMut2 ΔΔG:** not yet computed for this variant — AlphaMissense + AlphaFold
> confidence shown above. Stability ΔΔG and the wild-type/mutant structural
> comparison backfill behind this note.

---

## Clinical evidence

- **Classification:** Uncertain significance
- **Review status:** criteria provided, multiple submitters, no conflicts
- **cDNA change:** c.962C>T
- **ClinVar accession:** VCV001201617
- **Last evaluated:** 2025/05/23 00:00
- **Submissions:** 1

---

_Card generated by `wolfram-atlas-batch` (missense AlphaMissense mint) on 2026-06-08T02:27:33.455552Z._
_AlphaMissense (Cheng et al. 2023) · AlphaFold model v6 · UniProt O76024._