T490A
Category 4 — Stable Fold, Function DisruptedConflictingTransmembrane · predictedEditorialThr→Ala p490 loop AM=0.08 ddg=-0.34 pLDDT=81. ClinVar Conflicting evidence. Atlas mechanism: see structural analysis.
Interactive 3D Structure
Bond changes · DynaMut2 interaction analysis
| Interaction type | Wild-type partner | Mutant partner | Status |
|---|---|---|---|
| Hydrogen bond | L499 | L499 | Preserved |
| Hydrogen bond | N500 | — | Lost |
| Polar contact | L499 | L499 | Preserved |
| Polar contact | N500 | — | Lost |
| Carbonyl | L499 | — | Lost |
| Van der Waals | N500 | — | Lost |
| Hydrophobic | — | V498 | Gained |
Lost / gained / preserved interatomic contacts at the variant residue, from the DynaMut2 (Arpeggio) interaction analysis of the wild-type and energy-minimized mutant structures.
Computational Predictions
Clinical Evidence
Observed at very low frequency in gnomAD.
Structural Context
Position analysis: VAL491 (2.5 Å), ILE489 (2.5 Å — I489M!), LEU499 (3.5 Å — L499F partner!). Multi-variant target. The Atlas's neighbor extraction surfaces this variant's contacts and connects them to the broader multi-variant target landscape.
Druggability Assessment
Why this matters
Feed this card to Wolfram Intelligence
Download the T490A PDF below and upload it to Wolfram Intelligence to generate therapeutic-strategy proposals — guanidinium mimetics, sigma-1 agonist docking, NAC thiol-capping. NAC is already on the bench-testing list.