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V509G

AlphaMissense: likely benign (0.15)Uncertain significanceTransmembrane · predicted
Valine → Glycine at position 509 · Transmembrane helix 7 · WFS1 (Wolframin)

Interactive 3D Structure

Interactive structure
rotate · zoom · variant + 5 Å neighbors
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Computational Predictions

AlphaMissense
0.152
likely benign
AlphaFold pLDDT
85
model confidence
DynaMut2 ΔΔG
pending
not yet computed
ClinVar
Uncertain significance
Uncertain significance

AlphaMissense + AlphaFold card. This variant is mapped from AlphaMissense pathogenicity and AlphaFold confidence. The DynaMut2 ΔΔG stability prediction and the wild-type/mutant structural comparison (dual-pane + bond network) are computed per-variant and backfill here — they require a DynaMut2 submission, unlike the precomputed AlphaMissense score.

Clinical Evidence

ClinVar classificationUncertain significance
Review statuscriteria provided, multiple submitters, no conflicts
Associated conditionsCataract 41; Wolfram syndrome 1; Wolfram-like syndrome; Autosomal dominant nonsyndromic hearing loss 6; Type 2 diabetes mellitus
Population frequency (gnomAD v4)Ultra-rare · AF 0.00062%
cDNA changec.1526T>G
ClinVar accessionVCV002203520
Last evaluated2024/01/03 00:00

Observed at very low frequency in gnomAD.

Full Variant Card

V509G — WFS1 Molecular Atlas Card

Variant type: Missense Substitution: Valine (V) → Glycine (G) at position 509 Domain context: Transmembrane helix 7

AlphaMissense

  • Pathogenicity score: 0.1522
  • Class: likely benign

AlphaFold confidence

  • pLDDT at residue 509: 85.44

DynaMut2 ΔΔG: not yet computed for this variant — AlphaMissense + AlphaFold confidence shown above. Stability ΔΔG and the wild-type/mutant structural comparison backfill behind this note.

Clinical evidence

  • Classification: Uncertain significance
  • Review status: criteria provided, multiple submitters, no conflicts
  • Associated conditions: Cataract 41; Wolfram syndrome 1; Wolfram-like syndrome; Autosomal dominant nonsyndromic hearing loss 6; Type 2 diabetes mellitus
  • cDNA change: c.1526T>G
  • ClinVar accession: VCV002203520
  • Last evaluated: 2024/01/03 00:00
  • Submissions: 1

Card generated by wolfram-atlas-batch (missense AlphaMissense mint) on 2026-06-08T02:27:33.586451Z. AlphaMissense (Cheng et al. 2023) · AlphaFold model v6 · UniProt O76024.

Therapeutic Strategy Handoff · prediction

Feed this card to Wolfram Intelligence

Download the V509G PDF below and upload it to Wolfram Intelligence to generate therapeutic-strategy proposals — guanidinium mimetics, sigma-1 agonist docking, NAC thiol-capping. NAC is already on the bench-testing list.

Download V509G PDF card ↓Strategies are AI-generated predictions, not validated therapeutics.