# c.1419_1427del — WFS1 Molecular Atlas Card

**Variant type:** In-frame indel
**Change:** 3 residue(s) deleted in frame at position 473
**Domain context:** Transmembrane helix 6

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## Schema category: **I3 — Multi-residue in-frame indel — likely major structural disruption**

3 residues removed in frame around position 473 (Transmembrane helix 6). A change this size usually perturbs local packing and can propagate to the fold. Gene therapy is the primary path unless an AlphaFold prediction of the modified sequence shows a surprisingly intact fold. Predicted structure pending (ColabFold).

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## Structural prediction

- **Reading frame:** preserved (in-frame) — no premature stop, NMD does not apply.
- **Affected domain:** Transmembrane helix 6
- **Predicted modified structure:** _pending — AlphaFold/ColabFold prediction of the
  modified sequence and backbone-RMSD vs wild-type backfill here (Wave 2)._

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## Clinical evidence

- **Classification:** Uncertain significance
- **Review status:** criteria provided, single submitter
- **Associated conditions:** Autosomal dominant nonsyndromic hearing loss 6
- **cDNA change:** c.1419_1427del
- **ClinVar accession:** VCV003377401
- **Last evaluated:** 2022/03/31 00:00
- **Submissions:** 1

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_Card generated by `wolfram-atlas-batch` (in-frame indel pipeline) on 2026-06-08T02:41:13.790135Z._
_Schema: `reference/card_schema_extension.md` (I1–I3). WFS1: UniProt O76024, AlphaFold v6._