# T490= — WFS1 Molecular Atlas Card

**Variant type:** Synonymous (silent)
**Codon:** position 490 (Threonine, T) — amino acid unchanged
**Domain context:** Lumenal loop 3

---

## Schema category: **Silent — Silent — no amino-acid change**

No amino-acid change (T490 is unchanged): the codon is altered but the protein sequence is identical to wild-type. No structural, stability or AlphaMissense effect applies. Synonymous variants are typically benign unless they affect splicing or regulatory elements; this one is not adjacent to an exon boundary.

---

## Clinical evidence

- **Classification:** Benign/Likely benign
- **Review status:** criteria provided, multiple submitters, no conflicts
- **Associated conditions:** Wolfram syndrome 1; Wolfram-like syndrome; Autosomal dominant nonsyndromic hearing loss 6; Type 2 diabetes mellitus; Cataract 41
- **cDNA change:** c.1470C>T
- **ClinVar accession:** VCV000178592
- **Last evaluated:** 2025/11/11 00:00
- **Submissions:** 1

---

_Card generated by `wolfram-atlas-batch` (synonymous pipeline) on 2026-06-08T02:53:55.037855Z._
_WFS1: UniProt O76024, AlphaFold v6. Synonymous variants carry no protein-structural effect._