# A586= — WFS1 Molecular Atlas Card

**Variant type:** Synonymous (silent)
**Codon:** position 586 (Alanine, A) — amino acid unchanged
**Domain context:** Transmembrane helix 9

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## Schema category: **Silent — Silent — no amino-acid change**

No amino-acid change (A586 is unchanged): the codon is altered but the protein sequence is identical to wild-type. No structural, stability or AlphaMissense effect applies. Synonymous variants are typically benign unless they affect splicing or regulatory elements; this one is not adjacent to an exon boundary.

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## Clinical evidence

- **Classification:** Conflicting classifications of pathogenicity
- **Review status:** criteria provided, conflicting classifications
- **Associated conditions:** WFS1-Related Spectrum Disorders; Wolfram syndrome 1; Autosomal dominant nonsyndromic hearing loss 6
- **cDNA change:** c.1758C>T
- **ClinVar accession:** VCV000178595
- **Last evaluated:** 2026/03/01 00:00
- **Submissions:** 1

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_Card generated by `wolfram-atlas-batch` (synonymous pipeline) on 2026-06-08T02:54:55.812666Z._
_WFS1: UniProt O76024, AlphaFold v6. Synonymous variants carry no protein-structural effect._