# c.682_684del — WFS1 Molecular Atlas Card

**Variant type:** In-frame indel
**Change:** 1 residue(s) deleted in frame at position 228
**Domain context:** N-terminal cytoplasmic (intrinsically disordered)

---

## Schema category: **I2 — Single-residue deletion in a soluble domain — variable impact**

A single residue removed in N-terminal cytoplasmic (intrinsically disordered) (a soluble, non-membrane region) may be tolerated or may locally distort the domain. Worth pharmacological-chaperone exploration if AlphaFold predicts a near-native fold. Predicted structure pending (ColabFold).

---

## Structural prediction

- **Reading frame:** preserved (in-frame) — no premature stop, NMD does not apply.
- **Affected domain:** N-terminal cytoplasmic (intrinsically disordered)
- **Predicted modified structure:** _pending — AlphaFold/ColabFold prediction of the
  modified sequence and backbone-RMSD vs wild-type backfill here (Wave 2)._

---

## Clinical evidence

_Not found in the cached WFS1 ClinVar set (`_reference/WFS1_clinvar_variants.csv`)._

---

_Card generated by `wolfram-atlas-batch` (in-frame indel pipeline) on 2026-06-08T02:42:06.254545Z._
_Schema: `reference/card_schema_extension.md` (I1–I3). WFS1: UniProt O76024, AlphaFold v6._