RareResearch.AI
← Back to atlas

S855=

SynonymousSilentBenignLumenal · predicted
Synonymous variant · codon at position 855 · C-terminal ER-lumenal (calcium binding, calmodulin, chaperone) · WFS1 (Wolframin)

Silent — Silent — no amino-acid change

Interactive 3D Structure

Interactive structure
rotate · zoom · variant + 5 Å neighbors
Fullscreen ↗

AlphaFold wild-type wolframin · the variant site near residue 855 (C-terminal ER-lumenal (calcium binding, calmodulin, chaperone)) is highlighted.

Variant Assessment

Variant type
Synonymous
Schema
Silent
Silent — no amino-acid change
Domain
C-terminal ER-lumenal (calcium binding, calmodulin, chaperone)
Status
—

Therapeutic Implication · Silent

No amino-acid change (S855 is unchanged): the codon is altered but the protein sequence is identical to wild-type. No structural, stability or AlphaMissense effect applies. Synonymous variants are typically benign unless they affect splicing or regulatory elements; this one is not adjacent to an exon boundary.

Clinical Evidence

ClinVar classificationBenign
Review statuscriteria provided, multiple submitters, no conflicts
Associated conditionsWFS1-Related Spectrum Disorders; Autosomal dominant nonsyndromic hearing loss 6
Population frequency (gnomAD v4)Common · AF 69.92%
cDNA changec.2565A>G
Protein consequenceS855=
ClinVar variantNM_006005.3(WFS1):c.2565A>G (p.Ser855=)
ClinVar accessionVCV000045456
Last evaluated2026/02/04 00:00

Population frequency too high for a penetrant Wolfram allele — stand-alone benign evidence (ACMG BA1).

Therapeutic Strategy Handoff · prediction

Feed this card to Wolfram Intelligence

Download the S855= card below and upload it to Wolfram Intelligence to generate therapeutic-strategy proposals matched to this Silent synonymous variant and its domain context.

Download S855= PDF card ↓or markdown ↓

Full Variant Card

S855= — WFS1 Molecular Atlas Card

Variant type: Synonymous (silent) Codon: position 855 (Serine, S) — amino acid unchanged Domain context: C-terminal ER-lumenal (calcium binding, calmodulin, chaperone)

Schema category: Silent — Silent — no amino-acid change

No amino-acid change (S855 is unchanged): the codon is altered but the protein sequence is identical to wild-type. No structural, stability or AlphaMissense effect applies. Synonymous variants are typically benign unless they affect splicing or regulatory elements; this one is not adjacent to an exon boundary.

Clinical evidence

  • Classification: Benign
  • Review status: criteria provided, multiple submitters, no conflicts
  • Associated conditions: WFS1-Related Spectrum Disorders; Autosomal dominant nonsyndromic hearing loss 6
  • cDNA change: c.2565A>G
  • ClinVar accession: VCV000045456
  • Last evaluated: 2026/02/04 00:00
  • Submissions: 1

Card generated by wolfram-atlas-batch (synonymous pipeline) on 2026-06-08T02:56:47.019706Z. WFS1: UniProt O76024, AlphaFold v6. Synonymous variants carry no protein-structural effect.